Interactions between CD47 and thrombospondin reduce inflammation.

L, Lamy; A, Foussat; EJ, Brown; P, Bornstein; M, Ticchioni; A, Bernard

doi:10.4049/jimmunol.178.9.5930

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Interactions between CD47 and thrombospondin reduce inflammation.

Shared by NobleBlocks on May 1, 2007 • 12:00 AM UTC

Authors:

Lamy L

Foussat A

Brown EJ

Abstract

CD47 on the surface of T cells was shown in vitro to mediate either T cell activation or, in the presence of high amounts of thrombospondin (TSP), T cell apoptosis. We report here that CD47-deficient mice, as well as TSP-1 or TSP-2-deficient mice, sustain oxazolone-induced inflammation for more than...

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