Four Functionally Distinct Populations of Human Effector-Memory CD8+ T Lymphocytes

Romero, Pedro; Zippelius, Alfred; Kurth, Isabel; J. Pittet, Mikaël; Touvrey, Cédric; M. Iancu, Emanuela; Corthésy, Patricia; Devêvre, Estelle; E. Speiser, Daniel; Rufer, Nathalie

doi:10.4049/jimmunol.178.7.4112

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Four Functionally Distinct Populations of Human Effector-Memory CD8+ T Lymphocytes

Published in The Journal of Immunology • Apr 1, 2007

Authors:

Pedro Romero

Alfred Zippelius

Isabel Kurth

Abstract

In humans, the pathways of memory and effector T cell differentiation remain poorly defined. We have dissected the functional properties of ex vivo effector-memory (EM) CD45RA-CCR7- T lymphocytes present within the circulating CD8+ T cell pool of healthy individuals. Our studies show that EM T cells...

Subject

CD28

Interleukin-7 receptor

Biology

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