SIRT-1 and vascular endothelial dysfunction with ageing in mice and humans.

AJ, Donato; KA, Magerko; BR, Lawson; JR, Durrant; LA, Lesniewski; DR, Seals

doi:10.1113/jphysiol.2011.211219

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SIRT-1 and vascular endothelial dysfunction with ageing in mice and humans.

Shared by NobleBlocks on Jul 11, 2011 • 12:00 AM UTC

Authors:

Donato AJ

Magerko KA

Lawson BR

Abstract

We tested the hypothesis that reductions in the cellular deacetylase, sirtuin-1 (SIRT-1), contribute to vascular endothelial dysfunction with ageing via modulation of endothelial nitric oxide synthase (eNOS) acetylation/activation-associated nitric oxide (NO) production. In older (30 months, n = 14)...

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