Differential Immune Responses and Protective Efficacy Induced by Components of a Tuberculosis Polyprotein Vaccine, Mtb72F, Delivered as Naked DNA or Recombinant Protein

A. W. Skeiky, Yasir; R. Alderson, Mark; J. Ovendale, Pamela; A. Guderian, Jeffrey; Brandt, Lise; C. Dillon, Davin; Campos‐Neto, Antonio; Lobet, Yves; Dalemans, Wilfried; M. Orme, Ian; G. Reed, Steven

doi:10.4049/jimmunol.172.12.7618

Public

Differential Immune Responses and Protective Efficacy Induced by Components of a Tuberculosis Polyprotein Vaccine, Mtb72F, Delivered as Naked DNA or Recombinant Protein

Published in The Journal of Immunology • Jun 1, 2004

Authors:

Yasir A. W. Skeiky

Mark R. Alderson

Pamela J. Ovendale

Abstract

Key Ags of Mycobacterium tuberculosis initially identified in the context of host responses in healthy purified protein derivative-positive donors and infected C57BL/6 mice were prioritized for the development of a subunit vaccine against tuberculosis. Our lead construct, Mtb72F, codes for a 72-kDa ...

Subject

Tuberculosis vaccines

DNA vaccination

Adjuvant

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