MHC Class I/Peptide Transfer between Dendritic Cells Overcomes Poor Cross-Presentation by Monocyte-Derived APCs That Engulf Dying Cells

Qu, Chunfeng; Anh Nguyen, Van; Mérad, Miriam; J. Randolph, Gwendalyn

doi:10.4049/jimmunol.0801532

Public

MHC Class I/Peptide Transfer between Dendritic Cells Overcomes Poor Cross-Presentation by Monocyte-Derived APCs That Engulf Dying Cells

Published in The Journal of Immunology • Mar 1, 2009

Authors:

Chunfeng Qu

Van Anh Nguyen

Miriam Mérad

Abstract

In vivo data suggest that monocytes participate critically in cross-presentation, but other data suggest that lymph node resident dendritic cells (DCs) mainly cross-present. Here, we utilized a three-dimensional model of a blood vessel wall that endogenously supports DC development from human monocy...

Subject

Cross-presentation

MHC class II

Antigen presentation

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!