In vitro interactions between nuclear proteins and uncoupling protein gene promoter reveal several putative transactivating factors including Ets1, retinoid X receptor, thyroid hormone receptor, and a CACCC box-binding protein.

Cassard, Anne‐Marie; Larose, Marianne; Matamala, Juan; Champigny, O.; Bouillaud, Frédéric; Ricquier, Daniel

doi:10.1016/s0021-9258(19)51087-0

Public

In vitro interactions between nuclear proteins and uncoupling protein gene promoter reveal several putative transactivating factors including Ets1, retinoid X receptor, thyroid hormone receptor, and a CACCC box-binding protein.

Published in Journal of Biological Chemistry • Sep 1, 1994

Authors:

Anne‐Marie Cassard

Marianne Larose

Juan Matamala

Abstract

Previous studies of rat ucp (uncoupling protein) gene organization carried out in this laboratory identified regulatory sequences located in the 5'-flanking region. In this work, DNase I footprint analysis of the enhancer revealed two domains at base pairs (bp) -2444 to -2423 and bp -2352 to -2319. ...

Subject

Thyroid hormone receptor

Nuclear receptor

Thyroid hormone receptor beta

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