Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters.

Castagna, Marco; Takai, Yoshimi; Kaibuchi, Kozo; Sano, Ken‐Ichi; Kikkawa, Ushio; Nishizuka, Yasutomi

doi:10.1016/s0021-9258(18)34459-4

Public

Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters.

Published in Journal of Biological Chemistry • Jul 1, 1982

Authors:

Marco Castagna

Yoshimi Takai

Kozo Kaibuchi

Abstract

Tumor-promoting phorbol esters such as 12-O-tetradecanoylphorbol-13-acetate (TPA) directly activate in vitro Ca2+-activated, phospholipid-dependent protein kinase (protein kinase C), which normally requires unsaturated diacylglycerol. Kinetic analysis indicates that TPA can substitute for diacylglyc...

Subject

Protein kinase C

Phorbol ester

Phospholipid

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