An expression signature for p53 status in human breast cancer predicts mutation status, transcriptional effects, and patient survival

D. Miller, Lance; Smeds, Johanna; George, Joshy; B. Vega, Vinsensius; A. Vergara, Liza; Ploner, Alexander; Pawitan, Yudi; Hall, Per; Klaar, Sigrid; T. Liu, Edison; Bergh, Jonas

doi:10.1073/pnas.0506230102

Public

An expression signature for p53 status in human breast cancer predicts mutation status, transcriptional effects, and patient survival

Published in Proceedings of the National Academy of Sciences • Sep 2, 2005

Authors:

Lance D. Miller

Johanna Smeds

Joshy George

Abstract

Perturbations of the p53 pathway are associated with more aggressive and therapeutically refractory tumors. However, molecular assessment of p53 status, by using sequence analysis and immunohistochemistry, are incomplete assessors of p53 functional effects. We posited that the transcriptional finger...

Subject

Breast cancer

Biology

Cancer research

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