The mitochondria-targeted anti-oxidant mitoquinone decreases liver damage in a phase II study of hepatitis C patients

Gane, Edward; Weilert, Frank; Orr, David; F. Keogh, Geraldine; Gibson, Michael; Lockhart, Michelle; Frampton, Christopher; M. Taylor, Kenneth; A.J. Smith, Robin; P. Murphy, Michael

doi:10.1111/j.1478-3231.2010.02250.x

Public

The mitochondria-targeted anti-oxidant mitoquinone decreases liver damage in a phase II study of hepatitis C patients

Published in Liver International • May 18, 2010

Authors:

Edward Gane

Frank Weilert

David Orr

Abstract

BACKGROUND: Increased oxidative stress and subsequent mitochondrial damage are important pathways for liver damage in chronic hepatitis C virus (HCV) infection; consequently, therapies that decrease mitochondrial oxidative damage may improve outcome. The mitochondria-targeted anti-oxidant mitoquinon...

Subject

Alanine transaminase

Ribavirin

Oxidative stress

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