Involvement of Brain-Derived Neurotrophic Factor in Spatial Memory Formation and Maintenance in a Radial Arm Maze Test in Rats

Mizuno, Makoto; Yamada, Kiyofumi; Olariu, Ana; Nawa, Hiroyuki; Nabeshima, Toshitaka

doi:10.1523/jneurosci.20-18-07116.2000

Public

Involvement of Brain-Derived Neurotrophic Factor in Spatial Memory Formation and Maintenance in a Radial Arm Maze Test in Rats

Published in Journal of Neuroscience • Sep 15, 2000

Authors:

Makoto Mizuno

Kiyofumi Yamada

Ana Olariu

Abstract

Brain-derived neurotrophic factor (BDNF) regulates both short-term synaptic functions and activity-dependent synaptic plasticity such as long-term potentiation. In the present study, we investigated the role of BDNF in the spatial reference and working memory in a radial arm maze test. The radial ar...

Subject

Hippocampus

Long-term potentiation

Hippocampal formation

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