Decreased DNA-PK activity in human cancer cells exhibiting hypersensitivity to low-dose irradiation

Vaganay-Juéry, S; Muller, Catherine; Marangoni, Elisabetta; Abdulkarim, Bassam; Deutsch, Éric; Lambin, Philippe; Calsou, Patrick; Eschwège, F.; Salles, Bernard; C. Joiner, M.; Bourhis, Jean

doi:10.1054/bjoc.2000.1258

Public

Decreased DNA-PK activity in human cancer cells exhibiting hypersensitivity to low-dose irradiation

Published in British Journal of Cancer • Aug 1, 2000

Authors:

S Vaganay-Juéry

Catherine Muller

Elisabetta Marangoni

Abstract

Low-dose hyper-radiosensitivity (HRS) (below 0.5 Gy) has been extensively documented in the past few years. The molecular basis of this phenomenon remains largely unknown and the purpose of this study was to investigate the possible implication of the DNA repair DNA-PK complex. The activity of the D...

Subject

Radiosensitivity

DNA

DNA repair

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