The Major Synovial Targets of the Rheumatoid Arthritis-Specific Antifilaggrin Autoantibodies Are Deiminated Forms of the α- and β-Chains of Fibrin

Masson-Bessière, Christine; Sebbag, Mireille; Girbal‐Neuhauser, Elisabeth; Nogueira, Léonor; Vincent, Christian; Senshu, Tatsuo; Serre, Guy

doi:10.4049/jimmunol.166.6.4177

Public

The Major Synovial Targets of the Rheumatoid Arthritis-Specific Antifilaggrin Autoantibodies Are Deiminated Forms of the α- and β-Chains of Fibrin

Published in The Journal of Immunology • Mar 1, 2001

Authors:

Christine Masson-Bessière

Mireille Sebbag

Elisabeth Girbal‐Neuhauser

Abstract

IgG antifilaggrin autoantibodies (AFA) are the most specific serological markers of rheumatoid arthritis. In epithelial tissues, they recognize citrulline-bearing epitopes present on various molecular forms of (pro)filaggrin. Histological analysis of rheumatoid synovial membranes with an Ab to citru...

Subject

Autoantibody

Citrullination

Citrulline

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