Distinct, Specific IL-17- and IL-22-Producing CD4+ T Cell Subsets Contribute to the Human Anti-Mycobacterial Immune Response

J. Scriba, Thomas; Kalsdorf, Barbara; Abrahams, Deborah-Ann; Isaacs, Fatima; Hofmeister, Jessica; F. Black, Gillian; Y. Hassan, Hisham; J. Wilkinson, Robert; Walzl, Gerhard; Gelderbloem, Sebastian; Mahomed, Hassan; Hussey, Gregory; A. Hanekom, Willem

doi:10.4049/jimmunol.180.3.1962

Public

Distinct, Specific IL-17- and IL-22-Producing CD4+ T Cell Subsets Contribute to the Human Anti-Mycobacterial Immune Response

Published in The Journal of Immunology • Feb 1, 2008

Authors:

Thomas J. Scriba

Barbara Kalsdorf

Deborah-Ann Abrahams

Abstract

We investigated whether the proinflammatory T cell cytokines IL-17 and IL-22 are induced by human mycobacterial infection. Remarkably, >20% of specific cytokine-producing CD4(+) T cells in peripheral blood of healthy, mycobacteria-exposed adults expressed IL-17 or IL-22. Specific IL-17- and IL-22-pr...

Subject

Immune system

Immunology

Cytokine

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