Distinct, specific IL-17- and IL-22-producing CD4+ T cell subsets contribute to the human anti-mycobacterial immune response.

TJ, Scriba; B, Kalsdorf; DA, Abrahams; F, Isaacs; J, Hofmeister; G, Black; HY, Hassan; RJ, Wilkinson; G, Walzl; SJ, Gelderbloem; H, Mahomed; GD, Hussey; WA, Hanekom

doi:10.4049/jimmunol.180.3.1962

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Distinct, specific IL-17- and IL-22-producing CD4+ T cell subsets contribute to the human anti-mycobacterial immune response.

Shared by NobleBlocks on Feb 1, 2008 • 12:00 AM UTC

Authors:

Scriba TJ

Kalsdorf B

Abrahams DA

Abstract

We investigated whether the proinflammatory T cell cytokines IL-17 and IL-22 are induced by human mycobacterial infection. Remarkably, >20% of specific cytokine-producing CD4(+) T cells in peripheral blood of healthy, mycobacteria-exposed adults expressed IL-17 or IL-22. Specific IL-17- and IL-22-pr...

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