Mitochondrial DNA damage is more extensive and persists longer than nuclear DNA damage in human cells following oxidative stress

Michael Yakes, F.; Van Houten, Bennett

doi:10.1073/pnas.94.2.514

Public

Mitochondrial DNA damage is more extensive and persists longer than nuclear DNA damage in human cells following oxidative stress

Published in Proceedings of the National Academy of Sciences • Jan 21, 1997

Authors:

F. Michael Yakes

Bennett Van Houten

Abstract

A significant amount of reactive oxygen species (ROS) is generated during mitochondrial oxidative phosphorylation. Several studies have suggested that mtDNA may accumulate more oxidative DNA damage relative to nuclear DNA. This study used quantitative PCR to examine the formation and repair of hydro...

Subject

Mitochondrial DNA

DNA damage

Nuclear DNA

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