Genistein, a specific inhibitor of tyrosine-specific protein kinases.

Akiyama, Tetsu; Ishida, Junko; Nakagawa, Shizue; Ogawara, Hiroshi; Watanabe, Shun‐ichi; Itoh, Nobuko; Shibuya, Masabumi; Fukami, Yuko

doi:10.1016/s0021-9258(18)45614-1

Public

Genistein, a specific inhibitor of tyrosine-specific protein kinases.

Published in Journal of Biological Chemistry • Apr 1, 1987

Authors:

Tetsu Akiyama

Junko Ishida

Shizue Nakagawa

Abstract

Tyrosine-specific protein kinase activity of the epidermal growth factor (EGF) receptor, pp60v-src and pp110gag-fes was inhibited in vitro by an isoflavone genistein. The inhibition was competitive with respect to ATP and noncompetitive to a phosphate acceptor, histone H2B. By contrast, genistein sc...

Subject

Mitogen-activated protein kinase kinase

Tyrosine kinase

Platelet-derived growth factor receptor

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