MFG-E8 Attenuates Intestinal Inflammation in Murine Experimental Colitis by Modulating Osteopontin-Dependent αvβ3 Integrin Signaling

M. Aziz, Md.; Ishihara, Shunji; Mishima, Yoshiyuki; Oshima, Naoki; Moriyama, Ichiro; Yuki, Takafumi; Kadowaki, Yasunori; A. Karim Rumi, M.; Amano, Yuji; Kinoshita, Yoshikazu

doi:10.4049/jimmunol.0803711

Public

MFG-E8 Attenuates Intestinal Inflammation in Murine Experimental Colitis by Modulating Osteopontin-Dependent αvβ3 Integrin Signaling

Published in The Journal of Immunology • May 19, 2009

Authors:

Md. M. Aziz

Shunji Ishihara

Yoshiyuki Mishima

Abstract

MFG-E8 (milk fat globule-epidermal growth factor 8) deficiency is strongly associated with acquisition of immune-mediated disorders due to the loss of tissue homeostasis. However, comparatively little is known regarding its functions in gastrointestinal tract disorders, in which immune homeostasis i...

Subject

Colitis

Osteopontin

Inflammation

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