Uptake of insulin by plasmalemma and Golgi subcellular fractions of rat liver.

Following the portal vein injection of '261-insulin, radioactivity was taken up by rat liver and concentrated in microsomes (30 to 50% of homogenate).Subfractionation of microsomes revealed that 30 to 60% of the label accumulated in Golgi elements.Uptake was inhibited by co-injected unlabeled insuli... View More