The Roles of Toll-Like Receptor 9, MyD88, and DNA-Dependent Protein Kinase Catalytic Subunit in the Effects of Two Distinct CpG DNAs on Dendritic Cell Subsets

Hemmi, Hiroaki; Kaisho, Tsuneyasu; Takeda, Kiyoshi; Akira, Shizuo

doi:10.4049/jimmunol.170.6.3059

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The Roles of Toll-Like Receptor 9, MyD88, and DNA-Dependent Protein Kinase Catalytic Subunit in the Effects of Two Distinct CpG DNAs on Dendritic Cell Subsets

Shared by NobleBlocks on Mar 1, 2003 • 12:00 AM UTC

Authors:

Hiroaki Hemmi

Tsuneyasu Kaisho

Kiyoshi Takeda

Abstract

Abstract Oligodeoxynucleotides containing unmethylated CpG motifs (CpG DNAs) can function as powerful immune adjuvants by activating APC. Compared with conventional phosphorothioate-backbone CpG DNAs, another type of CpG DNAs, called an A or D type (A/D-type), possesses higher ability to induce IFN-...

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