Pharmacotherapy for Neurocognitive Disorders Based on the Hypothesis of Endogenous Appearance of Anticholinergic Activity

Hosoi, Misa; Hori, Koji; Konishi, Kimiko; Tani, Masayuki; Tomioka, Hiroi; Kitajima, Yuka; Akashi, Norihisa; Inamoto, Atsuko; Kurosawa, Kenzo; Yuda, Hajime; Hanashi, Takahiro; Ouchi, Hiromi; Hachisu, Mitsugu

doi:10.1159/000381513

Public

Pharmacotherapy for Neurocognitive Disorders Based on the Hypothesis of Endogenous Appearance of Anticholinergic Activity

Published in Neurodegenerative Diseases • Jan 1, 2015

Authors:

Misa Hosoi

Koji Hori

Kimiko Konishi

Abstract

We previously proposed the hypothesis of endogenous anticholinergic activity (AA) in Alzheimer's disease (AD). According to this hypothesis, the downregulation of acetylcholine seen in AD is associated with upregulation/hyperactivity of N-methyl-D-aspartate receptor (NMDAR). The hyperactivation of N...

Subject

Anticholinergic

Memantine

Donepezil

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!