Subtle shifts in the ratio between pro- and antiapoptotic molecules after activation of corticosteroid receptors decide neuronal fate.

OF, Almeida; GL, Condé; C, Crochemore; BA, Demeneix; D, Fischer; AH, Hassan; M, Meyer; F, Holsboer; TM, Michaelidis

doi:10.1096/fasebj.14.5.779

Public

Subtle shifts in the ratio between pro- and antiapoptotic molecules after activation of corticosteroid receptors decide neuronal fate.

Shared by NobleBlocks on Apr 1, 2000 • 12:00 AM UTC

Authors:

Almeida OF

Condé GL

Crochemore C

Abstract

Glucocorticoid receptor (GR) activation induces apoptosis of granule cells in the hippocampus. In contrast, neuroprotection is seen after mineralocorticoid receptor (MR) activation. To date there is no in vivo evidence for direct interactions between corticosteroids and any of the key regulatory mol...

Discussions