Cigarette Smoke-Induced Pulmonary Inflammation Is TLR4/MyD88 and IL-1R1/MyD88 Signaling Dependent

Doz, Emilie; Noulin, Nicolas; Boichot, Elisabeth; Guénon, Isabelle; Fick, Lizette; Le Bert, Marc; Lagente, Vincent; Ryffel, Bernhard; Schnyder, Bruno; Quesniaux, Valérie; Couillin, Isabelle

doi:10.4049/jimmunol.180.2.1169

Public

Cigarette Smoke-Induced Pulmonary Inflammation Is TLR4/MyD88 and IL-1R1/MyD88 Signaling Dependent

Published in The Journal of Immunology • Jan 1, 2008

Authors:

Emilie Doz

Nicolas Noulin

Elisabeth Boichot

Abstract

Acute cigarette smoke exposure of the airways (two cigarettes twice daily for three days) induces acute inflammation in mice. In this study, we show that airway inflammation is dependent on Toll-like receptor 4 and IL-1R1 signaling. Cigarette smoke induced a significant recruitment of neutrophils in...

Subject

TLR4

Inflammation

Proinflammatory cytokine

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