Methylene blue for malaria in Africa: results from a dose-finding study in combination with chloroquine

Meißner, Peter; Mandi, Germain; Coulibaly, Boubacar; Witte, Steffen; Tapsoba, Théophile; Mansmann, Ulrich; Rengelshausen, Jens; Schiek, W.; Jahn, Albrecht; Walter‐Sack, I.; Mikus, Gerd; Burhenne, Jürgen; Riedel, Klaus‐Dieter; Heiner Schirmer, R.; Kouyaté, Bocar; Müller, Olaf

doi:10.1186/1475-2875-5-84

Public

Methylene blue for malaria in Africa: results from a dose-finding study in combination with chloroquine

Published in Malaria Journal • Oct 8, 2006

Authors:

Peter Meißner

Germain Mandi

Boubacar Coulibaly

Abstract

The development of safe, effective and affordable drug combinations against malaria in Africa is a public health priority. Methylene blue (MB) has a similar mode of action as chloroquine (CQ) and has moreover been shown to selectively inhibit the Plasmodium falciparum glutathione reductase. In 2004,...

Subject

Malaria

Chloroquine

Plasmodium falciparum

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