Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Inhibitors: Rationale and Importance to Inhibiting These Pathways in Human Health

H. Chappell, William; S. Steelman, Linda; M. Long, Jacquelyn; C. Kempf, Ruth; L. Abrams, Stephen; A. Franklin, Richard; Bäsecke, Jörg; Stivala, Franca; Donia, Marco; Fagone, Paolo; Malaponte, Graziella; Clorinda Mazzarino, María; Nicoletti, Ferdinando; Libra, Massimo; Maksimović‐Ivanić, Danijela; Mijatović, Sanja; Montalto, Giuseppe; Cervello, Melchiorre; Laidler, Piotr; Milella, Michèle; Tafuri, Agostino; Bonati, Antonio; Evangelisti, Camilla; Cocco, Lucio; M. Martelli, Alberto; A. McCubrey, James

doi:10.18632/oncotarget.240

Public

Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Inhibitors: Rationale and Importance to Inhibiting These Pathways in Human Health

Published in Oncotarget • Mar 11, 2011

Authors:

William H. Chappell

Linda S. Steelman

Jacquelyn M. Long

Abstract

William H. Chappell 1 , Linda S. Steelman 1,2 , Jacquelyn M. Long 2 , Ruth C. Kempf 2 , Stephen L. Abrams 1 , Richard A. Franklin 1 , Jörg Bäsecke 3 , Franca Stivala 4 , Marco Donia 4 , Paolo Fagone 4 , Graziella Malaponte 4 , Maria C. Mazzarino 4 , Ferdinando Nicoletti 4 , Massimo Libra 4...

Subject

PTEN

PI3K/AKT/mTOR pathway

MAPK/ERK pathway

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