Prevention of Second Primary Tumors by an Acyclic Retinoid, Polyprenoic Acid, in Patients with Hepatocellular Carcinoma

Muto, Yasutoshi; Moriwaki, Hisataka; Ninomiya, Mitsuo; Adachi, Sadashi; Saito, Akiko; Takasaki, Ken; Tanaka, Takuji; Tsurumi, Kaito; Okuno, Masataka; Tomita, Eiichi; Nakamura, Toshiyuki; Kojima, Takao

doi:10.1056/nejm199606133342402

Public

Prevention of Second Primary Tumors by an Acyclic Retinoid, Polyprenoic Acid, in Patients with Hepatocellular Carcinoma

Published in New England Journal of Medicine • Jun 13, 1996

Authors:

Yasutoshi Muto

Hisataka Moriwaki

Mitsuo Ninomiya

Abstract

BACKGROUND: In patients with hepatocellular carcinoma (hepatoma), the rate of recurrent and second primary hepatomas is high despite surgical resection and percutaneous ethanol-injection therapy. We developed an acyclic retinoid, polyprenoic acid, that inhibits hepatocarcinogenesis in the laboratory...

Subject

Medicine

Hepatocellular carcinoma

Primary (astronomy)

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