The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C

Toullec, Dominique; Pianetti, P.; Coste, Hervé; Bellevergue, P.; Grand‐Perret, Thierry; Ajakane, M.; Baudet, V.; Boissin, P.; Boursier, Eric; Loriolle, F.

doi:10.1016/s0021-9258(18)98476-0

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The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C

Published in Journal of Biological Chemistry • Aug 1, 1991

Authors:

Dominique Toullec

P. Pianetti

Hervé Coste

Abstract

Staurosporine is the most potent inhibitor of protein kinase C (PKC) described in the literature with a half-maximal inhibitory concentration (IC50) of 10 nM. Nevertheless, this natural product is poorly selective when assayed against other protein kinases. In order to obtain specific PKC inhibitors...

Subject

Bisindolylmaleimide

Protein kinase C

Chemistry

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