Glucagon-like peptide 1 decreases lipotoxicity in non-alcoholic steatohepatitis

J. Armstrong, Matthew; Hull, Diana; Guo, Kathy; Barton, Darren; Hazlehurst, Jonathan; Gathercole, Laura; Nasiri, Maryam; Yu, Jinglei; Gough, Stephen; N. Newsome, Philip; Tomlinson, Jeremy

doi:10.1016/j.jhep.2015.08.038

Public

Glucagon-like peptide 1 decreases lipotoxicity in non-alcoholic steatohepatitis

Published in Journal of Hepatology • Sep 21, 2015

Authors:

Matthew J. Armstrong

Diana Hull

Kathy Guo

Abstract

BACKGROUND & AIMS: Insulin resistance and lipotoxicity are pathognomonic in non-alcoholic steatohepatitis (NASH). Glucagon-like peptide-1 (GLP-1) analogues are licensed for type 2 diabetes, but no prospective experimental data exists in NASH. This study determined the effect of a long-acting GLP-1 a...

Subject

Lipotoxicity

Steatohepatitis

Alcoholic liver disease

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