P2X<sub>3</sub>Knock-Out Mice Reveal a Major Sensory Role for Urothelially Released ATP

Vlaskovska, Mila; Kasakov, Lübomir; Rong, Weifang; Bodin, Philippe; Bardini, Michelle; A. Cockayne, Debra; Ford, Anthony; Burnstock, Geoffrey

doi:10.1523/jneurosci.21-15-05670.2001

Public

P2X3Knock-Out Mice Reveal a Major Sensory Role for Urothelially Released ATP

Published in Journal of Neuroscience • Aug 1, 2001

Authors:

Mila Vlaskovska

Lübomir Kasakov

Weifang Rong

Abstract

The present study explores the possible involvement of a purinergic mechanism in mechanosensory transduction in the bladder using P2X(3) receptor knock-out (P2X(3)-/-) and wild-type control (P2X(3)+/+) mice. Immunohistochemistry revealed abundant nerve fibers in a suburothelial plexus in the mouse b...

Subject

Purinergic receptor

Distension

Endocrinology

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