Excessive Proliferation Matched by Excessive Apoptosis in Myelodysplastic Syndromes: The Cause-Effect Relationship

Raza, Azra; Alvi, Sairah; Borok, Raphaelz; F. R. Span, Lambert; Parcharidou, Agapi; Alston, D.; Rifkin, Shelby; Robin, Erwin; Shah, Rohit; A. Gregory, Stephanie

doi:10.3109/10428199709068277

Public

Excessive Proliferation Matched by Excessive Apoptosis in Myelodysplastic Syndromes: The Cause-Effect Relationship

Published in Leukemia & lymphoma/Leukemia and lymphoma • Jan 1, 1997

Authors:

Azra Raza

Sairah Alvi

Raphaelz Borok

Abstract

The paradox of pancytopenia despite cellular bone marrows (BM) was investigated in 120 patients with myelodysplastic syndromes (MDS). Detailed cell cycle kinetics were examined following in vivo infusions of iodo--and/or bromodeoxyuridine (IUdR/BrdU), while the incidence of apoptosis was measured by...

Subject

Cytopenia

Pancytopenia

Apoptosis

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