Lewy body extracts from Parkinson disease brains trigger α‐synuclein pathology and neurodegeneration in mice and monkeys

Recasens, Ariadna; Dehay, Benjamin; Bové, Jordi; Carballo‐Carbajal, Iria; Doveró, Sandra; Pérez‐Villalba, Ana; Fernagut, Pierre‐Olivier; Blesa, Javier; Parent, Annabelle; Perier, Céline; Fariñas, Isabel; Á. Obeso, José; Bézard, Erwan; Vila, Miquel

doi:10.1002/ana.24066

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Lewy body extracts from Parkinson disease brains trigger α‐synuclein pathology and neurodegeneration in mice and monkeys

Published in Annals of Neurology • Nov 16, 2013

Authors:

Ariadna Recasens

Benjamin Dehay

Jordi Bové

Abstract

OBJECTIVE: Mounting evidence suggests that α-synuclein, a major protein component of Lewy bodies (LB), may be responsible for initiating and spreading the pathological process in Parkinson disease (PD). Supporting this concept, intracerebral inoculation of synthetic recombinant α-synuclein fibrils c...

Subject

Neurodegeneration

Parkinson's disease

Lewy body

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