Lewy body extracts from Parkinson disease brains trigger α‐synuclein pathology and neurodegeneration in mice and monkeys

Recasens, Ariadna; Dehay, Benjamin; Bové, Jordi; Carballo‐Carbajal, Iria; Dovero, Sandra; Pérez‐Villalba, Ana; Fernagut, Pierre‐Olivier; Blesa, Javier; Parent, Annabelle; Perier, Celine; Fariñas, Isabel; A. Obeso, José; Bezard, Erwan; Vila, Miquel

doi:10.1002/ana.24066

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Lewy body extracts from Parkinson disease brains trigger α‐synuclein pathology and neurodegeneration in mice and monkeys

Shared by NobleBlocks on Feb 18, 2014 • 12:00 AM UTC

Authors:

Ariadna Recasens

Benjamin Dehay

Jordi Bové

Abstract

Objective Mounting evidence suggests that α‐synuclein, a major protein component of Lewy bodies (LB), may be responsible for initiating and spreading the pathological process in Parkinson disease (PD). Supporting this concept, intracerebral inoculation of synthetic recombinant α‐synuclein fibrils ca...

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