Lewy body extracts from Parkinson disease brains trigger α-synuclein pathology and neurodegeneration in mice and monkeys.

Recasens, Ariadna; Dehay, Benjamin; Bové, Jordi; Carballo-Carbajal, Iria; Dovero, Sandra; Pérez-Villalba, Ana; Fernagut, Pierre-Olivier; Blesa, Javier; Parent, Annabelle; Perier, Celine; Fariñas, Isabel; A Obeso, José; Bezard, Erwan; Vila, Miquel

doi:10.1002/ana.24066

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Lewy body extracts from Parkinson disease brains trigger α-synuclein pathology and neurodegeneration in mice and monkeys.

Shared by NobleBlocks on Mar 1, 2014 • 12:00 AM UTC

Authors:

Ariadna Recasens

Benjamin Dehay

Jordi Bové

Abstract

OBJECTIVE: Mounting evidence suggests that α-synuclein, a major protein component of Lewy bodies (LB), may be responsible for initiating and spreading the pathological process in Parkinson disease (PD). Supporting this concept, intracerebral inoculation of synthetic recombinant α-synuclein fibrils c...

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