Schwann Cell Proliferative Responses to cAMP and<i>Nf1</i>Are Mediated by Cyclin D1

A. Kim, Haesun; Ratner, Nancy; M. Roberts, Thomas; D. Stiles, Charles

doi:10.1523/jneurosci.21-04-01110.2001

Public

Schwann Cell Proliferative Responses to cAMP andNf1Are Mediated by Cyclin D1

Shared by NobleBlocks on Feb 15, 2001 • 12:00 AM UTC

Authors:

Haesun A. Kim

Nancy Ratner

Thomas M. Roberts

Abstract

In most mammalian cells, the cAMP-dependent protein kinase A pathway promotes growth arrest and cell differentiation. However in Schwann cells, the reverse is true. Elevated levels of cAMP function as the cofactor to a broad range of mitogenic cues in culture and in animals. Previous studies have su...

Subject

Cyclin D1

Cell biology

Biology

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