Essential Role of MD-2 in TLR4-Dependent Signaling during Helicobacter pylori -Associated Gastritis

Ishihara, Shunji; A. Karim Rumi, M.; Kadowaki, Yasunori; F. Ortega-Cava, Cesar; Yuki, Takafumi; Yoshino, Nagisa; Miyaoka, Youichi; Kazumori, Hideaki; Ishimura, Norihisa; Amano, Yuji; Kinoshita, Yoshikazu

doi:10.4049/jimmunol.173.2.1406

Public

Essential Role of MD-2 in TLR4-Dependent Signaling during Helicobacter pylori -Associated Gastritis

Published in The Journal of Immunology • Jul 1, 2004

Authors:

Shunji Ishihara

M. A. Karim Rumi

Yasunori Kadowaki

Abstract

TLR4, a member of pattern recognition receptors, is the main receptor of LPS. MD-2 physically associates with TLR4 on the cell surface and confers LPS responsiveness. Helicobacter pylori LPS is one of the major virulence factors for induction of gastritis. We demonstrated in this study the role of M...

Subject

Helicobacter pylori

TLR4

Gastritis

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