Hypoxic tumor-derived microvesicles negatively regulate NK cell function by a mechanism involving TGF-β and miR23a transfer

Berchem, Guy; Zaeem Noman, Muhammad; Bosseler, Manon; Paggetti, Jérôme; Baconnais, Sonia; Le Cam, Éric; Nanbakhsh, Arash; Moussay, Etienne; Mami‐Chouaib, Fathia; Janji, Bassam; Chouaı̈b, Salem

doi:10.1080/2162402x.2015.1062968

Public

Hypoxic tumor-derived microvesicles negatively regulate NK cell function by a mechanism involving TGF-β and miR23a transfer

Published in OncoImmunology • Jun 24, 2015

Authors:

Guy Berchem

Muhammad Zaeem Noman

Manon Bosseler

Abstract

Tumor-derived microvesicles (TD-MVs) are key mediators which are shed by cancer cells and can sensitize neighboring cells in the tumor microenvironment. TD-MVs are extracellular vesicles composed of exosomes and MVs and promote cancer invasion and metastasis. Intratumoral hypoxia is an integral comp...

Subject

Microvesicles

Tumor microenvironment

NKG2D

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