Exosomes as Potent Cell-Free Peptide-Based Vaccine. I. Dendritic Cell-Derived Exosomes Transfer Functional MHC Class I/Peptide Complexes to Dendritic Cells

André, Fabrice; Chaput, Nathalie; E C Schartz, Nöel; Flament, Caroline; Aubert, Nathalie; Bernard, Jacky; Lemonnier, François; Raposo, Graça; Escudier, Bernard; Hsu, Di-Hwei; Tursz, Thomas; Amigorena, Sebastian; Angevin, Eric; Zitvogel, Laurence

doi:10.4049/jimmunol.172.4.2126

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Exosomes as Potent Cell-Free Peptide-Based Vaccine. I. Dendritic Cell-Derived Exosomes Transfer Functional MHC Class I/Peptide Complexes to Dendritic Cells

Shared by NobleBlocks on Feb 1, 2004 • 12:00 AM UTC

Authors:

Fabrice André

Nathalie Chaput

Nöel E C Schartz

Abstract

Abstract Current immunization protocols in cancer patients involve CTL-defined tumor peptides. Mature dendritic cells (DC) are the most potent APCs for the priming of naive CD8+ T cells, eventually leading to tumor eradication. Because DC can secrete MHC class I-bearing exosomes, we addressed whethe...

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