Definition of a consensus integrin adhesome and its dynamics during adhesion complex assembly and disassembly

R. Horton, Edward; Byron, Adam; A. Askari, Janet; Ng, Daniel; Millon‐Frémillon, Angélique; Robertson, Joseph; Koper, Ewa; R. Paul, Nikki; Warwood, Stacey; Knight, David; D. Humphries, Jonathan; J. Humphries, Martin

doi:10.1038/ncb3257

Public

Definition of a consensus integrin adhesome and its dynamics during adhesion complex assembly and disassembly

Published in Nature Cell Biology • Oct 19, 2015

Authors:

Edward R. Horton

Adam Byron

Janet A. Askari

Abstract

Integrin receptor activation initiates the formation of integrin adhesion complexes (IACs) at the cell membrane that transduce adhesion-dependent signals to control a multitude of cellular functions. Proteomic analyses of isolated IACs have revealed an unanticipated molecular complexity; however, a ...

Subject

Integrin

Cell biology

Paxillin

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