FcγRIIa Is Expressed on Natural IFN-α-Producing Cells (Plasmacytoid Dendritic Cells) and Is Required for the IFN-α Production Induced by Apoptotic Cells Combined with Lupus IgG

Båve, Ullvi; Magnusson, Mattias; Eloranta, Maija-Leena; Perers, Anders; V Alm, Gunnar; Rönnblom, Lars

doi:10.4049/jimmunol.171.6.3296

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FcγRIIa Is Expressed on Natural IFN-α-Producing Cells (Plasmacytoid Dendritic Cells) and Is Required for the IFN-α Production Induced by Apoptotic Cells Combined with Lupus IgG

Shared by NobleBlocks on Sep 1, 2003 • 12:00 AM UTC

Authors:

Ullvi Båve

Mattias Magnusson

Maija-Leena Eloranta

Abstract

Abstract An ongoing production of IFN-α may be of etiopathogenic significance in systemic lupus erythematosus (SLE). It may be due to the natural IFN-producing cells (NIPC), also termed plasmacytoid dendritic cells (PDC), activated by immune complexes that contain nucleic acids derived from apoptoti...

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