Circulating and Liver Resident CD4+CD25+ Regulatory T Cells Actively Influence the Antiviral Immune Response and Disease Progression in Patients with Hepatitis B

Xu, Dongping; Fu, Junliang; Jin, Lei; Zhang, Hui; Zhou, Chun‐Bao; Zou, Zhengsheng; Zhao, Jing-Min; Zhang, Bin; Shi, Ming; Ding, Xilai; Tang, Zirong; Fu, Yang‐Xin; Wang, Fu‐Sheng

doi:10.4049/jimmunol.177.1.739

Public

Circulating and Liver Resident CD4+CD25+ Regulatory T Cells Actively Influence the Antiviral Immune Response and Disease Progression in Patients with Hepatitis B

Published in The Journal of Immunology • Jul 1, 2006

Authors:

Dongping Xu

Junliang Fu

Lei Jin

Abstract

CD4+CD25+ regulatory T cells (Treg) have been shown to maintain immune tolerance against self and foreign Ags, but their role in persistent viral infection has not been well-defined. In this study, we investigated whether and where CD4+CD25+ Treg contribute to the development of chronic hepatitis B ...

Subject

IL-2 receptor

Immunology

FOXP3

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