CD73 expression on extracellular vesicles derived from CD4+CD25+Foxp3+ T cells contributes to their regulatory function

A. Smyth, Lesley; Ratnasothy, Kulachelvy; Y. Tsang, Julia; A. Boardman, Dominic; Warley, Alice; I. Lechler, Robert; Lombardi, Giovanna

doi:10.1002/eji.201242909

Public

CD73 expression on extracellular vesicles derived from CD4+CD25+Foxp3+ T cells contributes to their regulatory function

Shared by NobleBlocks on Jun 10, 2013 • 12:00 AM UTC

Authors:

Lesley A. Smyth

Kulachelvy Ratnasothy

Julia Y. Tsang

Abstract

CD4(+)CD25(+)Foxp3(+) Treg cells maintain immunological tolerance. In this study, the possibility that Treg cells control immune responses via the production of secreted membrane vesicles, such as exosomes, was investigated. Exosomes are released by many cell types, including T cells, and have regul...

Subject

Biology

Extracellular vesicles

Function (biology)

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