IκBα Deficiency Results in a Sustained NF-κB Response and Severe Widespread Dermatitis in Mice

The ubiquitous transcription factor NF-kappaB is an essential component in signal transduction pathways, in inflammation, and in the immune response. NF-kappaB is maintained in an inactive state in the cytoplasm by protein-protein interaction with IkappaBalpha. Upon stimulation, rapid degradation of... View More