IL-4 is an essential factor for the IgE synthesis induced in vitro by human T cell clones and their supernatants.

Del Prete, Gianfranco; Maggi, Enrico; Parronchi, Paola; Chrétien, Isabelle; Tiri, A; Macchia, Donatella; Ricci, M; Banchereau, Jacques; de Vries, Jan; Romagnani, Sergio

doi:10.4049/jimmunol.140.12.4193

Public

IL-4 is an essential factor for the IgE synthesis induced in vitro by human T cell clones and their supernatants.

Published in The Journal of Immunology • Jun 1, 1988

Authors:

Gianfranco Del Prete

Enrico Maggi

Paola Parronchi

Abstract

The property of 109 CD4+ T cell clones (TCC) to induce IgE synthesis in vitro in human B cells was compared with their ability to produce IL-2, IL-4, and IFN-gamma in their supernatants (SUP) after 24-h stimulation with PHA. A significant positive correlation was found between the property of TCC to...

Subject

Immunoglobulin E

Interleukin 4

In vitro

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