Thyroid hormone induces activation of mitogen-activated protein kinase in cultured cells

Thyroid hormone [l-thyroxine (T 4 )] rapidly induced phosphorylation and nuclear translocation (activation) of mitogen-activated protein kinase (MAPK) in HeLa and CV-1 cells in the absence of cytokine or growth factor. A pertussis toxin-sensitive and guanosine 5′- O-(3-thiotriphosphate)-sensitive ce... View More