Relaxation of Loaded ESCRT-III Spiral Springs Drives Membrane Deformation

Chiaruttini, Nicolas; Redondo‐Morata, Lorena; Colom, Adai; Humbert, Frédéric; Lenz, Martin; Scheuring, Simon; Roux, Aurélien

doi:10.1016/j.cell.2015.10.017

Public

Relaxation of Loaded ESCRT-III Spiral Springs Drives Membrane Deformation

Published in Cell • Nov 1, 2015

Authors:

Nicolas Chiaruttini

Lorena Redondo‐Morata

Adai Colom

Abstract

ESCRT-III is required for lipid membrane remodeling in many cellular processes, from abscission to viral budding and multi-vesicular body biogenesis. However, how ESCRT-III polymerization generates membrane curvature remains debated. Here, we show that Snf7, the main component of ESCRT-III, polymeri...

Subject

Biology

ESCRT

Spiral (railway)

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