Vemurafenib in Multiple Nonmelanoma Cancers with <i>BRAF</i> V600 Mutations

M. Hyman, David; Puzanov, Igor; Subbiah, Vivek; E. Faris, Jason; Chau, Ian; Blay, Jean‐Yves; Wolf, Jürgen; Raje, Noopur; L. Diamond, Eli; Hollebecque, Antoine; Gervais, Radj; Elena Elez-Fernandez, Maria; Italiano, Antoîne; Hofheinz, Ralf‐Dieter; Hidalgo, Manuel; Chan, Emily; Schüler, Martin; Frances Lasserre, Susan; Makrutzki, Martina; Sirzén, Florin; Luisa Veronese, Maria; Tabernero, Josep; Baselga, José

doi:10.1056/nejmoa1502309

Public

Vemurafenib in Multiple Nonmelanoma Cancers with BRAF V600 Mutations

Published in New England Journal of Medicine • Aug 19, 2015

Authors:

David M. Hyman

Igor Puzanov

Vivek Subbiah

Abstract

BACKGROUND: BRAF V600 mutations occur in various nonmelanoma cancers. We undertook a histology-independent phase 2 "basket" study of vemurafenib in BRAF V600 mutation-positive nonmelanoma cancers. METHODS: We enrolled patients in six prespecified cancer cohorts; patients with all other tumor types w...

Subject

Medicine

Vemurafenib

Internal medicine

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