Cytokine Production Regulating Th1 and Th2 Cytokines in Hemophagocytic Lymphohistiocytosis

Osugi, Yuko; Hara, Junichi; Tagawa, S; Takai, Kenji; Hosoi, Gaku; Matsuda, Yoshiko; Ohta, Hideaki; Fujisaki, Hiroyuki; Kobayashi, Michiko; Sakata, Naoki; Kawa‐Ha, Keisei; Okada, Shintaro; Tawa, Akio

doi:10.1182/blood.v89.11.4100

Public

Cytokine Production Regulating Th1 and Th2 Cytokines in Hemophagocytic Lymphohistiocytosis

Published in Blood • Jun 1, 1997

Authors:

Yuko Osugi

Junichi Hara

S Tagawa

Abstract

Hemophagocytic lymphohistiocytosis (HLH) is caused by the hyperactivation of T cells and macrophages. The clinical characteristics associated with this disease result from overproduction of Th1 cytokines including interferon-gamma (IFN-gamma), interleukin-2 (IL-2), and tumor necrosis factor-alpha (T...

Subject

Cytokine

Tumor necrosis factor alpha

Interleukin 10

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