Mangifera indica L. Extract and Mangiferin Modulate Cytochrome P450 and UDP‐Glucuronosyltransferase Enzymes in Primary Cultures of Human Hepatocytes

Rodeiro, Idania; José Gómez‐Lechón, M.; Pérez, Gabriela; Hernández, Ivones; Herrera, J.; Delgado, René; V. Castell, José; Teresa Donato, M.

doi:10.1002/ptr.4782

Public

Mangifera indica L. Extract and Mangiferin Modulate Cytochrome P450 and UDP‐Glucuronosyltransferase Enzymes in Primary Cultures of Human Hepatocytes

Published in Phytotherapy Research • Jul 20, 2012

Authors:

Idania Rodeiro

M. José Gómez‐Lechón

Gabriela Pérez

Abstract

The aqueous stem bark extract of Mangifera indica L. (MSBE) has been reported to have antioxidant, anti-inflammatory and analgesic properties. In previous studies, we showed that MSBE and mangiferin, its main component, lower the activity of some cytochrome P-450 (P450) enzymes in rat hepatocytes an...

Subject

Mangiferin

CYP1A2

CYP2A6

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