Identification of the Heme Compound Copurified with Deoxyribonucleic Acid (DNA) from Bloodstains, a Major Inhibitor of Polymerase Chain Reaction (PCR) Amplification

Akane, Atsushi; Matsubara, Kiminori; Nakamura, Hiroaki; Takahashi, Sei; Kimura, Kojiro

doi:10.1520/jfs13607j

Public

Identification of the Heme Compound Copurified with Deoxyribonucleic Acid (DNA) from Bloodstains, a Major Inhibitor of Polymerase Chain Reaction (PCR) Amplification

Published in Journal of Forensic Sciences • Mar 1, 1994

Authors:

Atsushi Akane

Kiminori Matsubara

Hiroaki Nakamura

Abstract

The heme compound found in deoxyribonucleic acid (DNA) extracted from bloodstains, which is regarded as a major inhibitor of polymerase chain reaction (PCR), was characterized in comparison with alkaline and acid hematin, histidine and ammonia hemochromogens, and globin and serum albumin hemochromog...

Subject

Heme

Chemistry

Proteinase K

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