IL-6 is produced by osteoblasts and induces bone resorption.

Ishimi, Yoshiko; Miyaura, Chisato; Jin, Cheng; Akatsu, Takuhiko; Abe, E.; Nakamura, Yasushi; Yamaguchi, Akira; Yoshiki, Shusaku; Matsuda, Takako; Hirano, Tsutomu; Kishimoto, T; Suda, T

doi:10.4049/jimmunol.145.10.3297

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IL-6 is produced by osteoblasts and induces bone resorption.

Published in The Journal of Immunology • Nov 1, 1990

Authors:

Yoshiko Ishimi

Chisato Miyaura

Cheng Jin

Abstract

To examine the possible involvement of IL-6 in bone metabolism, a mouse osteoblastic cell line (MC3T3-E1) and primary osteoblast-like cells from fetal mouse calvaria were cultured with several systemic and local bone-resorbing agents and their expression of IL-6 mRNA was determined. Local bone-resor...

Subject

Calvaria

Osteoblast

Bone resorption

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