Whole-genome sequencing for prediction of Mycobacterium tuberculosis drug susceptibility and resistance: a retrospective cohort study

Sarah Walker, A; A. Kohl, Thomas; Vally Omar, Shaheed; Hedge, Jessica; del Ojo Elías, Carlos; Bradley, Phelim; Iqbal, Zamin; Feuerriegel, Silke; E. Niehaus, Katherine; J. Wilson, Daniel; A. Clifton, David; Kapatai, Georgia; L. C. Ip, Camilla; Bowden, Rory; Drobniewski, Francis; Allix‐Béguec, Caroline; Gaudin, Cyril; Parkhill, Julian; Diel, Roland; Supply, Philip; W. Crook, Derrick; Grace Smith, E.; Sarah Walker, A; Ismail, Nazir; Niemann, Stefan; Peto, Tim

doi:10.1016/s1473-3099(15)00062-6

Public

Whole-genome sequencing for prediction of Mycobacterium tuberculosis drug susceptibility and resistance: a retrospective cohort study

Published in The Lancet Infectious Diseases • Jun 24, 2015

Authors:

A Sarah Walker

Thomas A. Kohl

Shaheed Vally Omar

Abstract

BACKGROUND: Diagnosing drug-resistance remains an obstacle to the elimination of tuberculosis. Phenotypic drug-susceptibility testing is slow and expensive, and commercial genotypic assays screen only common resistance-determining mutations. We used whole-genome sequencing to characterise common and...

Subject

Mycobacterium tuberculosis

Drug resistance

Tuberculosis

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