Pharmacokinetics of caffeine in plasma and saliva, and the influence of caffeine abstinence on CYP1A2 metrics

Perera, Vidya; S. Gross, Annette; Xu, Hongmei; J. McLachlan, Andrew

doi:10.1111/j.2042-7158.2011.01326.x

Public

Pharmacokinetics of caffeine in plasma and saliva, and the influence of caffeine abstinence on CYP1A2 metrics

Published in Journal of Pharmacy and Pharmacology • Jul 6, 2011

Authors:

Vidya Perera

Annette S. Gross

Hongmei Xu

Abstract

OBJECTIVES: To investigate the utility of metrics of CYP1A2 activity using caffeine as a probe, and saliva and plasma sampling with or without a 24-h caffeine abstinence. METHODS: This was a cross-over pharmacokinetic study in 30 healthy male subjects who received a single oral 100mg caffeine dose a...

Subject

Paraxanthine

Caffeine

Saliva

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