Genetic variation in <i><scp>DNMT3B</scp></i> and increased global <scp>DNA</scp> methylation is associated with suicide attempts in psychiatric patients

M. Murphy, Therese; Mullins, Niamh; Ryan, Maria; Foster, Tom; Kelly, Chris; McClelland, Robert; O’Grady, John; Corcoran, Eleanor; Brady, Jeff; J. Reilly, Michael; Jeffers, Anne; Brown, Katherine; Maher, Anthony; Bannan, Noreen; Casement, Alison; H. Lynch, Derek; Bolger, S.; Buckley, Alexandra; Quinlivan, Leah; Daly, Leslie; Kelleher, Cecily; Malone, Kevin

doi:10.1111/j.1601-183x.2012.00865.x

Public

Genetic variation in DNMT3B and increased global DNA methylation is associated with suicide attempts in psychiatric patients

Published in Genes Brain & Behavior • Oct 1, 2012

Authors:

Therese M. Murphy

Niamh Mullins

Maria Ryan

Abstract

Recently, a significant epigenetic component in the pathology of suicide has been realized. Here we investigate candidate functional SNPs in epigenetic-regulatory genes, DNMT1 and DNMT3B, for association with suicide attempt (SA) among patients with co-existing psychiatric illness. In addition, glob...

Subject

DNA methylation

DNMT3B

Haplotype

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