Discovery and Fine-Mapping of Glycaemic and Obesity-Related Trait Loci Using High-Density Imputation

Horikoshi, Momoko; Mägi, Reedik; van de Bunt, Martijn; Surakka, Ida; Sarin, Antti‐Pekka; Mahajan, Anubha; Marullo, Letizia; Þorleifsson, Guðmar; Hägg, Sara; Hottenga, Jouke‐Jan; Ladenvall, Claes; S. Ried, Janina; W. Winkler, Thomas; M. Willems, Sara; Pervjakova, Natalia; Esko, Tõnu; Beekman, Marian; P. Nelson, Christopher; Willenborg, Christina; Wiltshire, Steven; Ferreira, Teresa; Fernandez, Juan; J. Gaulton, Kyle; Steinthórsdóttir, Valgerður; Hamsten, Anders; K. E. Magnusson, Patrik; Willemsen, Gonneke; Milaneschi, Yuri; R. Robertson, Neil; J. Groves, Christopher; J. Bennett, Amanda; Lehtimäki, Terho; Viikari, Jorma; Rung, Johan; Lyssenko, Valeriya; Perola, Markus; M. Heid, Iris; Herder, Christian; Grallert, Harald; Müller‐Nurasyid, Martina; Roden, Michael; Hyppönen, Elina; Isaacs, Aaron; M. van Leeuwen, Elisabeth; C. Karssen, Lennart; Mihailov, Evelin; J. Houwing‐Duistermaat, Jeanine; J. M. de Craen, Anton; Deelen, Joris; S. Havulinna, Aki; Blades, Matthew; Hengstenberg, Christian; Erdmann, Jeanette; Schunkert, Heribert; Kaprio, Jaakko; D. Tobin, Martin; J. Samani, Nilesh; Lind, Lars; Salomaa, Veikko; M. Lindgren, Cecilia; Eline Slagboom, P.; Metspalu, Andres; M. van Duijn, Cornelia; G. Eriksson, Johan; Peters, Annette; Gieger, Christian; Jula, Antti; Groop, Leif; T. Raitakari, Olli; Power, Chris; W.J.H. Penninx, Brenda; J. C. de Geus, Eco; H. Smit, Johannes; I. Boomsma, Dorret; L. Pedersen, Nancy; Ingelsson, Erik; Þorsteinsdóttir, Unnur; Stefánsson, Kāri; Ripatti, Samuli; Prokopenko, Inga; I. McCarthy, Mark; P. Morris, Andrew

doi:10.1371/journal.pgen.1005230

Public

Discovery and Fine-Mapping of Glycaemic and Obesity-Related Trait Loci Using High-Density Imputation

Published in PLoS Genetics • Jul 1, 2015

Authors:

Momoko Horikoshi

Reedik Mägi

Martijn van de Bunt

Abstract

Reference panels from the 1000 Genomes (1000G) Project Consortium provide near complete coverage of common and low-frequency genetic variation with minor allele frequency ≥0.5% across European ancestry populations. Within the European Network for Genetic and Genomic Epidemiology (ENGAGE) Consortium,...

Subject

Genome-wide association study

Biology

Imputation (statistics)

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